The story primarily concerns the difficult relationship between two women, Helen Francine Peters (referred to as Francine throughout the series) and Katina Marie ("Katchoo") Choovanski, and their friend David Qin. Francine considers Katchoo her best friend; Katchoo is in love with Francine. David is in love with Katchoo (a relationship which Katchoo herself is deeply conflicted over).
The love triangle (which later expands into a love rectangle with the introduction of Casey Bullock, who marries Francine's ex-boyfriend Freddie Femur and later divorces him, in order to pursue both David and Katchoo) alternates with the mystery and intrigue regarding Katchoo's past as an underage lesbian hooker and the Parker Crime Syndicate. Run by David's lesbian sister Darcy, the "Parker Girls" work for the shadowy 'Big Six' organization, an international crime syndicate with influence over the world of politics. "Parker Girls" are highly trained women used by organized crime to control, manipulate, spy upon, and ultimately kill men and women in positions of power and authority, for the Big Six.