Wormwood, Jimmy, Jay all return and the world hasn't gotten any better since their last adventure. Wormwood still produces questionable TV shows and pines for Maggie, his lost love. The boys all share drinks at their favorite pub and try to get on with their lives, but Pope Jacko has his own plans for Wormwood. In order to dispatch the Anti-Christ once-and-for-all, he dispatches his finest Holy assassin, Brother One, the Killer Eunuch!