Once more Spider-Man and Daredevil team up against a bar full of super villains, or at least lesser known rouges. After winning Daredevil and Spidey meet up at a rooftop, where Spider-Man decides to tell Daredevil his secret identity. Daredevil stops him and mentions that somehow his powers are blocking him from knowing so that means he shouldn't really know. Daredevil swings away while Peter enters the offices of Front Line to give the picture of the most recent heroic effort of Spider-Man. Both Robbie Robertson and Norah leave the Front Line to go to J.J.J Sr. and May's Rehearsal Dinner, something that Peter fails to go to because he was at the paper. From various monitors one of May's old flames is watching closely, Doctor Octopus. The next day is the wedding but everything goes wrong, The catering service is shut down, the ceremony performer is no longer certified, and the marriage license record is erased. Jonah Sr. thinks of this as an act of his son and confronts him on a press conference about Swimsuit models. May goes to the cemetery and confronts her husband's grave asking if it is right for her to be married and doubts the fact she has his blessing. Peter tries to invite Carlie Cooper as his "plus one " for the wedding but she tells him she already has an invitation and a plus one. They both agree on meeting up at Jonah Sr.'s apartment after May tell Peter something terrible has happened. As Spider-Man he heads there but is confronted with the city. New York starts attacking Spidey and the man behind it is reveals himself as Doctor Octopus. Carlie goes to the apartment and instead of Peter finds Norah trying to break in. They both enter the apartment to find it trashed completely. Since New York is out to get Spider-Man (or at least Doctor Octopus controlling the New York) and he is endangering innocent people the New Avengers join in the fight to protect him. At the same time the Fantastic Four are trying to stop this their own way. Carlie and Norah are on the investigation on what happened to J.J.J Sr. and get caught during it all. Peter listens through the phone as Carlie and Norah get taken away and heads to the FF for help. Johnny decides to help since he thinks the girls Peter knows are hot. They both track the girls into Doc Ock's lair where it's discovered Doc Ock has four extra arms and his body is no longer functioning, as in Doc Ock is now just a machine. Carlie, Norah and Jonah are made undergo the same process but The Human Torch and Spider-Man free them. After a heated battle between the Doc and Spidey, Octavius flees along with his new machinery. With his brains Spider-Man stops New York from going haywire using Reed Richard's methods before he can apply them himself. The Wedding is back on and even Johnny Storm is going, as Carlie Cooper's "plus one". Back at his apartment Peter is getting ready but has no "plus one" to take with him. Michelle Gonzales, his roommate, offers to be taken with him. The wedding starts and finally J. Jonah Jameson Sr. and May Reily Parker get married. At the bouquet toss an unexpected guest catches the bouquet. Anna Watson's "plus one" arrives, Mary Jane.